Infections from CVC in the pediatric neoplastic patient. Single institution experience.
Minerva Pediatr
; 64(4): 385-94, 2012 Aug.
Article
em En, It
| MEDLINE
| ID: mdl-22728610
ABSTRACT
AIM:
The present clinical study was carried out in order to evaluate in a perspective way the incidence of the infections caused by CVC, the micro-organisms mostly involved in the infectious process, the condition of aplasia in patients when blood cultures show positiveness and the incidence of removals expressed as number of performed removals/number of positive blood culture.METHODS:
Between January 2003 and December 2009 452 blood cultures from CVC were carried out on 120 patients affected by acute lymphoblastyic and myelougenous leukemia (38), Hodgkin and non-Hodgkin lymphoma (17) and solid tumors (65), with an average of 65 blood cultures per year showing an average positiveness of 21 cases/year. The blood cultures were performed, in hyperpyrexia, when there was a clinical suspicion of infection from CVC.RESULTS:
On 452 blood cultures from CVC carried out (31.4% positive per Gram +, 53.7% per Gram-, 14.9% per miceti) 128 (28.3%) resulted positive, excluding presumed contaminations. They were divided as follows 21 of Staphylococcus epidermidis (16%), 10 of Escherichia coli (8%), 10 of Klebsiella pneumoniae (8%), 8 of Pseudomonas aeruginosa (6%), 8 of Staphylococcus aureus (6%), 6 of Enterobacter cloacae (5%), 4 of Candida parapsilosis (3%) and 61 of other micro-organisms (48%). It was necessary to perform 27 CVC removals. The micro-organisms most frequently involved in removals of the CVC were finally analyzed and the resulting frequency percentages are - 85% for Gram- germs; -8% for Gram + germs; -7% for Mycete.CONCLUSION:
Our clinical study has confirmed that in pediatric age neoplastic individuals there is a prevalence of CVC-correlated infections from Gram- and an elevated association of removals of the CVC caused by infections from Pseudomonas and Klebsiella, germs more frequently associated to clinical conditions of marked aplastic anemia.
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Base de dados:
MEDLINE
Assunto principal:
Cateterismo Venoso Central
/
Protocolos de Quimioterapia Combinada Antineoplásica
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Infecções por Bactérias Gram-Positivas
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Infecções por Bactérias Gram-Negativas
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Bacteriemia
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Infecções Relacionadas a Cateter
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Neoplasias
Idioma:
En
/
It
Ano de publicação:
2012
Tipo de documento:
Article