Photoisomerizable arylstilbazolium ligands recognize parallel and antiparallel structures of G-quadruplexes.
Int J Biol Macromol
; 51(4): 576-82, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22750579
ABSTRACT
The photoisomerization and DNA interaction studies of three arylstilbazolium derivatives with various samples of nucleic acids (duplexes, triplexes and tetraplexes) are reported. The equilibrium dialysis study revealed high binding affinities of ligands to tetraplex structures. The quadruplex-binding affinity could be switched by light, e.g., the E,E and E,Z isomers of 1,4-bis(vinylquinolinium)benzene (1) interacted with parallel and antiparallel tetraplexes exhibiting different binding selectivity. The E,Z-1 showed higher binding preference for c-myc DNA (a propeller-type quadruplex), whereas the E,E-1 favorably interacted with telomeric DNA (a basket-type quadruplex). The presence of quadruplex DNA hampered photoisomerization of quadruplex-bound ligand.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Benzilideno
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DNA
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Quadruplex G
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Processos Fotoquímicos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article