In situ electrostimulation drives a regenerative shift in the zone of infarcted myocardium.
Cell Transplant
; 22(3): 493-503, 2013.
Article
em En
| MEDLINE
| ID: mdl-22776240
ABSTRACT
Electrostimulation represents a well-known trophic factor for different tissues. In vitro electrostimulation of non-stem and stem cells induces myogenic predifferentiation and may be a powerful tool to generate cells with the capacity to respond to local areas of injury. We evaluated the effects of in vivo electrostimulation on infarcted myocardium using a miniaturized multiparameter implantable stimulator in rats. Parameters of electrostimulation were organized to avoid a direct driving or pacing of native heart rhythm. Electrical stimuli were delivered for 14 days across the scar site. In situ electrostimulation used as a cell-free, cytokine-free stimulation system, improved myocardial function, and increased angiogenesis through endothelial progenitor cell migration and production of vascular endothelial growth factor (VEGF). In situ electrostimulation represents a novel means to stimulate repair of the heart and other organs, as well as to precondition tissues for treatment with cell-based therapies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estimulação Elétrica
/
Infarto do Miocárdio
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article