Histocompatibility and in vivo signal throughput for PEDOT, PEDOP, P3MT, and polycarbazole electrodes.
J Biomed Mater Res A
; 100(12): 3455-62, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22821813
ABSTRACT
Stimulation and recording of the in vivo electrical activity of neurons are critical functions in contemporary biomedical research and in treatment of patients with neurological disorders. The electrodes presently in use tend to exhibit short effective lifespans due to degradation of signal transmission resulting from the tissue response at the electrode-brain interface, with signal throughput suffering most at the low frequencies relevant for biosignals. To overcome these limitations, new electrode designs to minimize tissue responses, including conducting polymers (CPs) have been explored. Here, we report the short-term histocompatibility and signal throughput results comparing platinum and CP-modified platinum electrodes in a Sprague-Dawley rat model. Two of the polymers tested elicited significantly decreased astrocyte responses relative to platinum. These polymers also showed improved signal throughput at low frequencies and comparable signal-to-noise ratios during targeted intracranial electroencephalograms. These results suggest that CP electrodes may present viable alternatives to the metal electrodes that are currently in use.
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1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
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Pirróis
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Tiofenos
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Teste de Materiais
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Processamento de Sinais Assistido por Computador
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Carbazóis
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Compostos Bicíclicos Heterocíclicos com Pontes
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Eletrodos Implantados
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article