3-Nitro-2H-chromenes as a new class of inhibitors against thioredoxin reductase and proliferation of cancer cells.
Arch Pharm (Weinheim)
; 345(10): 767-70, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22836584
ABSTRACT
A series of 3-nitrochromenes were designed and synthesized. These compounds showed good inhibitory activity against thioredoxin reductase (TrxR) and the proliferation of A549 cancer cells. The structure-activity relationship analysis indicates that the 3-nitrochromene scaffold is the crucial pharmacophore for achieving good inhibitory activity. The bromo-substitutions at the 6- and 8-position of 3-nitrochromene significantly increase the inhibitory activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tiorredoxina Dissulfeto Redutase
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Benzopiranos
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Inibidores Enzimáticos
/
Nitrocompostos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article