Inactivation of the ybdD gene in Lactococcus lactis increases the amounts of exported proteins.
Appl Environ Microbiol
; 78(19): 7148-51, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22843524
ABSTRACT
Random insertional mutagenesis performed on a Lactococcus lactis reporter strain led us to identify L. lactis ybdD as a protein-overproducing mutant. In different expression contexts, the ybdD mutant shows increased levels of exported proteins and therefore constitutes a new and attractive heterologous protein production host. This study also highlights the importance of unknown regulatory processes that play a role during protein secretion.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Lactococcus lactis
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article