[Pulmonary aspergillosis due to methimazole-induced neutropenia: a case report]. / Aspergilosis pulmonar secundaria a neutropenia inducida por metimazol: reporte de un caso.
Rev Peru Med Exp Salud Publica
; 29(2): 255-8, 2012 Jun.
Article
em Es
| MEDLINE
| ID: mdl-22858775
ABSTRACT
A 48-year old woman with a recent diagnosis of Graves' disease arrived at the emergency room with fever, palpitations, and a sore throat. Her regular treatment included methimazole. On admission, laboratory results showed suppressed TSH, elevated free thyroxine, and neutropenia. She was admitted and started on antibiotics and granulocyte-macrophage colony stimulating factor (gm-csf). After ten days, the patient developed leukocytosis, fever, and hemoptysis. Chest CT scan showed a lung cavity with multiple nodules in the upper right lobe. Cultures from a lung biopsy were positive for Aspergillus Fumigatus and Aspergillus Flavus. Amphotericin B was started but then switched to voriconazole, with both treatments failing to result in clinical improvement. The patient died of multi-organ failure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antitireóideos
/
Aspergilose Pulmonar
/
Metimazol
/
Neutropenia
Idioma:
Es
Ano de publicação:
2012
Tipo de documento:
Article