Effect of chronic emotional and pain stress on histone H3 phosphorylation in the hippocampus of rat strains with different excitability of the nervous system.
Bull Exp Biol Med
; 153(3): 357-60, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22866311
ABSTRACT
Long-term effects of chronic emotional and pain stress on histone H3 phosphorylation by serine 10 in hippocampal CA3 neurons were examined 24 h, 2 weeks, and 2 months after termination of the stress procedure in 2 rat strains differing by excitability of the nervous system. The low excitable rats with high threshold (HT) of excitability were characterized by a high baseline level of histone H3 phosphorylation in comparison with the high excitable rats with low threshold (LT) of excitability. The long-term emotional and pain stress significantly changed the number of positive immune cells in highly excitable rats this parameter increased in 24 h and 2 weeks after the stress, but returned to the control level in 2 months. In contrast, stress did not affect histone H3 phosphorylation in low excitable rats. Thus, long-term (up to 2 weeks) changes in histone H3 phosphorylation were reveled in rat hippocampal CA3 neurons, which depended on genetically determined functional status of the nervous system.
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Base de dados:
MEDLINE
Assunto principal:
Dor
/
Estresse Psicológico
/
Histonas
/
Hipocampo
/
Sistema Nervoso
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article