Hippo inactivation feeds tumor-initiating cells.
Breast Cancer Res
; 14(4): 318, 2012 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-22866917
ABSTRACT
The Hippo pathway has emerged as a well-conserved kinase cascade controlling cell proliferation and survival and has recently gained much attention for its key activity as a tumor suppressor. In a study published in Cell, Cordenonsi and colleagues link TAZ, a downstream effector of the Hippo pathway, to attributes of putative breast cancer stem cells, epithelial-to-mesenchymal transition and cell polarity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Neoplasias da Mama
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Proteínas Serina-Treonina Quinases
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article