Chemical functionalization of bioceramics to enhance endothelial cells adhesion for tissue engineering.
J Med Chem
; 55(18): 7988-97, 2012 Sep 27.
Article
em En
| MEDLINE
| ID: mdl-22897452
ABSTRACT
To control the selective adhesion of human endothelial cells and human serum proteins to bioceramics of different compositions, a multifunctional ligand containing a cyclic arginine-glycine-aspartate (RGD) peptide, a tetraethylene glycol spacer, and a gallate moiety was designed, synthesized, and characterized. The binding of this ligand to alumina-based, hydroxyapatite-based, and calcium phosphate-based bioceramics was demonstrated. The conjugation of this ligand to the bioceramics induced a decrease in the nonselective and integrin-selective binding of human serum proteins, whereas the binding and adhesion of human endothelial cells was enhanced, dependent on the particular bioceramics.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
/
Cerâmica
/
Engenharia Tecidual
/
Células Endoteliais da Veia Umbilical Humana
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article