A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii.
Bioorg Med Chem Lett
; 22(18): 5819-22, 2012 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-22901896
ABSTRACT
A new C-methylated flavone glycoside, 5,7-dihydroxy-3-methoxy-6-C-methylflavone 8,4'-di-O-ß-D-glucopyranoside (1), was isolated from the twigs and leaves of Picea neoveitchii Mast, together with eight known compounds, 5,7,8,4'-tetrahydroxy-3-methoxy-6-methylflavone 8-O-ß-D-glucopyranoside (2) kaempferol 3,4'-di-O-ß-D-glucopyranoside (3), apigenin 7-O-ß-D-glucopyranoside (4), tiliroside (5), massonianoside B (6), umbeliferone 7-O-ß-D-glucopyranoside (7), dihydroconiferin (8) and gleditschiaside A (9). Their structures were elucidated on the basis of analyses of spectroscopic data. Compound 1 showed moderate antifungal activity against tested plant pathogens (Pyricularia grisea (Cooke) Sacc., Sclerotium rocfsii Sacc. and Alternaria mali Roberts), however, compounds 2 and 5 had obvious inhibitory effect against S. rocfsii and A. mali, respectively. Compounds 1, 2, 3 and 9 also exhibited potent cytotoxicity against Spodoptera litura Fabricius cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Spodoptera
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Picea
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Flavonas
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Fungos
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Glicosídeos
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Antifúngicos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article