Duplication of 8q12 encompassing CHD7 is associated with a distinct phenotype but without duane anomaly.
Eur J Med Genet
; 55(11): 646-9, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22902603
ABSTRACT
Interstitial duplications of 8q12 encompassing CHD7 have recently been described as a new microduplication syndrome. Three 8q12 duplications have been reported with shared recognizable phenotype Duane anomaly, developmental delay and dysmorphic facial features. We identified a 2.7 Mb duplication on chromosome 8q12 with SNP-array in a patient with growth delay, congenital heart defects, ear anomalies and torticollis. To our knowledge, this is the smallest duplication reported to date. Our findings support the notion that increased copy number of CHD7 may underlie the phenotype of the 8q12 duplication. Our study together with previous studies suggest that the 8q12 duplication could be defined as a novel syndrome.
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Base de dados:
MEDLINE
Assunto principal:
Fenótipo
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Cromossomos Humanos Par 8
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DNA Helicases
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Transtornos Cromossômicos
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Proteínas de Ligação a DNA
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Duplicação Cromossômica
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article