[Progress in the ligands and their complex structures of farnesoid X receptor].
Yao Xue Xue Bao
; 47(6): 704-15, 2012 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-22919716
ABSTRACT
Farnesoid X receptor (FXR) belongs to the nuclear receptor superfamily. It is highly related to the formation of metabolic syndrome and the glucose homeostasis, and therefore represents an important drug target against metabolic diseases and diabetes. In recent years, great progress has been made in the agonists, antagonists, and crystal structures of FXR. The diverse FXR ligands and their structure-activity relationship are reviewed in this article. The advances in the crystal structures of FXR in complex with different ligands are also introduced.
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Base de dados:
MEDLINE
Assunto principal:
Receptores Citoplasmáticos e Nucleares
/
Complexos Multienzimáticos
Idioma:
Zh
Ano de publicação:
2012
Tipo de documento:
Article