A toxic substance produced by Nocardia otitidiscaviarum isolated from cutaneous nocardiosis.
Mycopathologia
; 112(2): 113-8, 1990 Nov.
Article
em En
| MEDLINE
| ID: mdl-2293032
ABSTRACT
During our studies on toxic substances from clinically isolated Nocarida, a new isolate identified as Nocardia otitidiscaviarum from cutaneous nocardiosis was found to produce a toxic substance called HS-6 that had strong in vitro as well as in vivo toxicity. The mouse intraperitoneal LD50 value was 1.25 mg/kg and the ED50 value for L1210 cultured cells was 0.3 ng/ml. The structure of HS-6 was determined and found to belong to the 16-membered macrocyclic group with a molecular formula of C43H68O12. HS-6 also showed activity against pathogenic fungi such as Cryptococcus neoformans.
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Base de dados:
MEDLINE
Assunto principal:
Dermatopatias Infecciosas
/
Toxinas Bacterianas
/
Nocardia
/
Nocardiose
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article