An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques.
Sci Transl Med
; 4(150): 150ra123, 2012 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-22956201
ABSTRACT
Microbicides may prevent HIV and sexually transmitted infections (STIs) in women; however, determining the optimal means of delivery of active pharmaceutical ingredients remains a major challenge. We previously demonstrated that a vaginal gel containing the non-nucleoside reverse transcriptase inhibitor MIV-150 partially protected macaques from SHIV-RT (simian/HIV reverse transcriptase) infection, and the addition of zinc acetate rendered the gel significantly protective. We test the activity of MIV-150 without the addition of zinc acetate when delivered from either ethylene vinyl acetate (EVA) or silicone intravaginal rings (IVRs). MIV-150 was successfully delivered, because it was detected in vaginal fluids and tissues by radioimmunoassay in pharmacokinetic studies. Moreover, EVA IVRs significantly protected macaques from SHIV-RT infection. Our results demonstrate that MIV-150-containing IVRs have the potential to prevent HIV infection and highlight the possible use of IVRs for delivering drugs that block HIV and other STIs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Ureia
/
Síndrome de Imunodeficiência Adquirida dos Símios
/
Inibidores da Transcriptase Reversa
/
Dispositivos Anticoncepcionais Femininos
/
Macaca
/
Nucleosídeos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article