Epigenetic landscape and miRNA involvement during neural crest development.
Dev Dyn
; 241(12): 1849-56, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22972707
ABSTRACT
The neural crest (NC) is a multipotent, migratory cell population that arises from the dorsal neural fold of vertebrate embryos. NC cells migrate extensively and differentiate into a variety of tissues, including melanocytes, bone, and cartilage of the craniofacial skeleton, peripheral and enteric neurons, glia, and smooth muscle and endocrine cells. For several years, the gene regulatory network that orchestrates NC cells development has been extensively studied. However, we have recently begun to understand that epigenetic and posttranscriptional regulation, such as miRNAs, plays important roles in NC development. In this review, we focused on some of the most recent findings on chromatin-dependent mechanisms and miRNAs regulation during vertebrate NC cells development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
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Movimento Celular
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MicroRNAs
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Epigênese Genética
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Embrião de Mamíferos
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Crista Neural
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article