Colon neoplastic cells do not originate from bone marrow-derived cells after sex-mismatched bone marrow transplantation.
Anticancer Res
; 32(9): 4097-103, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22993367
ABSTRACT
BACKGROUND:
Although previous studies indicate that gastrointestinal (GI) cancer may originate from cells recruited from bone marrow (BM) in mice, whether similar phenomena occur in humans is controversial. In the current study, we evaluated two female patients who developed colonic adenocarcinoma more than 10 years after gender-mismatched BM transplantation, and followingly underwent successful endoscopic mucosal resection. MATERIALS ANDMETHODS:
Fluorescent in situ hybridization (FISH) analysis was used to determine whether the tumours contained donor-derived BM cells.RESULTS:
Approximately 1.2% of the tumour cells contained Y-chromosome-positive signals, and a comparable percentage of normal colonic epithelial cells close to the tumour also contained Y-chromosome-positive signals.CONCLUSION:
These results do not support the concept that GI cancer can originate from BM-derived cells.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Células da Medula Óssea
/
Adenocarcinoma
/
Transplante de Medula Óssea
/
Neoplasias do Colo
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article