Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53.
Exp Toxicol Pathol
; 65(5): 677-82, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-22999639
ABSTRACT
Egr-1 and p53 are involved in pathology of both atherosclerosis and cancer. However, it is unknown whether p53 and Egr1 are interactively involved in apoptosis in atherosclerosis. We found that in human carotid plaques, the expression of p53 was inversely correlated with Egr1. In U937 cells, 7ß-hydroxycholesterol and 7-ketocholesterol induced production of reactive oxygen species (ROS), transient up-regulation of Egr1 followed by late induction of p53 and apoptosis. Cells with nuclear fragmentation induced by 7-oxysterol or p53 showed increased levels of p53, but decreased levels of Egr1. In conclusion, ROS induced by 7-oxysterols may function as an early initiator of Egr1 expression. The late induced p53 by 7-oxysterols contributes to apoptotic cell death and is linked to the reduction of Egr1 levels, which resembles the differential expression of p53 and Egr1 in human atheroma progression.
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Base de dados:
MEDLINE
Assunto principal:
Proteína Supressora de Tumor p53
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Estenose das Carótidas
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Apoptose
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Proteína 1 de Resposta de Crescimento Precoce
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Hidroxicolesteróis
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Cetocolesteróis
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article