Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature.
BMC Cancer
; 12: 424, 2012 Sep 25.
Article
em En
| MEDLINE
| ID: mdl-23006472
ABSTRACT
BACKGROUND:
Pulmonary carcinosarcoma is a biphasic tumour with an unfavourable prognosis. The differential diagnosis includes pulmonary blastoma and is often challenging. CASE PRESENTATION We here describe a case of blastomatoid pulmonary carcinosarcoma in a 58-year-old patient, who underwent surgical resection. Histopathological examination revealed immature glandular epithelium resembling high-grade fetal adenocarcinoma expressing epithelial markers and membranous beta-catenin, and blastomatoid spindle cells with partial rhabdomyosarcoma-like differentiation. Both elements expressed p53, MDM2, and cyclin-dependent kinase 4 (CDK4), but not thyroid-transcription factor 1 (TTF-1). Mutation analysis of KRAS, EGFR, and beta-catenin revealed no mutations. Comparative genomic hybridization detected +1q, +6p, +6q24qter, +8q, +11q12q14, +11q23qter, +12q12q21, +12q24qter, +17q, +20q, -5q14q23, -9p13pter, -13q21q21, and amplifications at 12q14q21, 15q24qter, 20q11q12.CONCLUSION:
The observed molecular and cytogenetic findings may provide additional tools for the differential diagnosis of biphasic pulmonary neoplasms. Furthermore, TP53, MDM2, CDK4, and PTPN1 may be involved in tumourigenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carcinossarcoma
/
Blastoma Pulmonar
/
Pulmão
/
Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article