Exploring chemical diversity via a modular reaction pairing strategy.
Beilstein J Org Chem
; 8: 1293-302, 2012.
Article
em En
| MEDLINE
| ID: mdl-23019462
ABSTRACT
The efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (S(N)Ar) diversification pathway is reported. Eight benzofused sultam cores were generated by means of a sulfonylation/S(N)Ar/Mitsunobu reaction pairing protocol, and subsequently diversified by intermolecular S(N)Ar with ten chiral, non-racemic amine/amino alcohol building blocks. Computational analyses were employed to explore and evaluate the chemical diversity of the library.
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MEDLINE
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En
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2012
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Article