A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.
Cancer Lett
; 328(2): 278-84, 2013 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-23059759
ABSTRACT
FAM3B mRNA has been predicted to have multiple splicing forms. Its secretory form PANDER is decreased in gastric cancers with high invasiveness and metastasis. Here we found that its non-secretory form FAM3B-258 was highly expressed in most colon cancer cell lines and colorectal adenocarcinoma tissues but not hepatocellular carcinoma, lung carcinoma and pancreatic adenocarcinoma cell lines. Elevation of FAM3B-258 was associated with poor cancer cell differentiation. Stable overexpression of FAM3B-258 in colon cancer cells downregulated adhesion proteins, upregulated Slug and Cdc42, promoted cell migration and invasion in vitro and metastasis in nude mice. Slug mediated FAM3B-258-induced downregulation of adhesion molecules, upregulation of Cdc42, and invasion of colon cancer cells. The expression of FAM3B-258 in human colorectal adenocarcinomas was positively correlated with Slug. These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Adenocarcinoma
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Regulação Neoplásica da Expressão Gênica
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Citocinas
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Neoplasias do Colo
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Proteínas de Neoplasias
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article