MT1 melatonin receptor expression in Warthin's tumor.
Pathol Oncol Res
; 19(2): 247-50, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23073719
ABSTRACT
We contribute the first immunohistochemical study of MT1 melatonin receptor in Warthin's tumor and normal parotid gland. All 14 Warthin's tumors studied showed intense cytoplasmic positivity for MT1 receptor in all cylindrical epithelial cells lining spaces and a less intense positivity in basal cells. The lymphoid component accompanying the tumor was always negative for MT1 receptor. The parotid structure surrounding the tumor showed intense cytoplasmic positivity in all cells lining excretory ducts (lobar and lobulillar), with a lesser and focal positivity in cells of the acinar component. The biological activity of MT1 receptor in epithelial cells lining parotid excretory ducts may resemble its activity in Warthin's tumor cells. Hence, we propose Warthin's tumor as a useful positive control in immunohistochemical studies of MT1 melatonin receptor.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adenolinfoma
/
Receptor MT1 de Melatonina
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article