12-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy?
Sci Rep
; 2: 765, 2012.
Article
em En
| MEDLINE
| ID: mdl-23097687
ABSTRACT
We have interrogated a 12-chemokine gene expression signature (GES) on genomic arrays of 14,492 distinct solid tumors and show broad distribution across different histologies. We hypothesized that this 12-chemokine GES might accurately predict a unique intratumoral immune reaction in stage IV (non-locoregional) melanoma metastases. The 12-chemokine GES predicted the presence of unique, lymph node-like structures, containing CD20⺠B cell follicles with prominent areas of CD3⺠T cells (both CD4⺠and CD8⺠subsets). CD86âº, but not FoxP3âº, cells were present within these unique structures as well. The direct correlation between the 12-chemokine GES score and the presence of unique, lymph nodal structures was also associated with better overall survival of the subset of melanoma patients. The use of this novel 12-chemokine GES may reveal basic information on in situ mechanisms of the anti-tumor immune response, potentially leading to improvements in the identification and selection of melanoma patients most suitable for immunotherapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quimiocinas
/
Linfonodos
/
Melanoma
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article