Enantioselective synthesis of a hydroxymethyl-cis-1,3-cyclopentenediol building block.
Org Lett
; 14(22): 5716-9, 2012 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-23101616
ABSTRACT
A brief, enantioselective synthesis of a hydroxymethyl-cis-1,3-cyclopentenediol building block is presented. This scaffold allows access to the cis-1,3-cyclopentanediol fragments found in a variety of biologically active natural and non-natural products. This rapid and efficient synthesis is highlighted by the utilization of the palladium-catalyzed enantioselective allylic alkylation of dioxanone substrates to prepare tertiary alcohols.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paládio
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Ciclopentanos
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Dioxanos
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Álcoois
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article