Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety.
Bioorg Med Chem Lett
; 22(24): 7688-92, 2012 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-23102889
ABSTRACT
New quinolone derivatives bearing a cis- or trans-cyclohexane side chain at the C-7 position have been synthesized and evaluated for their antibacterial activities against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa using the agar dilution method. The activities of compound 53 against these three bacteria were superior to those of the reference drug lomefloxacin. Compounds bearing a cis-cyclohexane side chain generally exhibited greater antibacterial activity than their corresponding trans-isomers.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
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Staphylococcus aureus
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Cicloexanos
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Fluoroquinolonas
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Escherichia coli
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Antibacterianos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article