Protective effect of anthocyanin from Lonicera Caerulea var. Edulis on radiation-induced damage in mice.
Int J Mol Sci
; 13(9): 11773-11782, 2012.
Article
em En
| MEDLINE
| ID: mdl-23109882
ABSTRACT
The radioprotective effect of anthocyanin extracted from Lonicera caerulea var. edulis (ALC), was studied in ICR mice. Different doses of ALC were intragastrically administered to mice once a day, prior to radiation. After two weeks, the mice received a one-time 5 Gy whole body (60)Coγ radiation. The spleen index, thymus index, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content, and glutathione (GSH) content in liver tissue were measured. Compared with the radiation control group, the levels of MDA in all ALC treated groups decreased significantly (p < 0.05). Moreover, the GSH content, activities of SOD and GSH-Px in liver tissue were enhanced significantly (p < 0.05) in all ALC groups. These results demonstrate that ALC may be a potential radioprotector, and a further study of the molecular mechanism is needed for further application.
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Base de dados:
MEDLINE
Assunto principal:
Lesões Experimentais por Radiação
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Protetores contra Radiação
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Lonicera
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Raios gama
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Antocianinas
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article