[Production of timolol containing calcium-phosphate nanoparticles and evaluation of their effect on intraocular pressure in experiment].
Vestn Oftalmol
; 128(3): 15-8, 2012.
Article
em Ru
| MEDLINE
| ID: mdl-23120918
ABSTRACT
Methodology for production of calcium-phosphate nanoparticles is developed and its efficacy as a drug carrier system is estimated by example of timolol. Conditions for production of particles with optimal size and resistance are determined, methodology of loading of particles with timolol is developed. Physical parameters of particles (form, size, relief), kinetics of saturation with drug and its release are studied. Packaging of timolol into calcium phosphate nanoparticles was showed to enhance and prolong its hypotensive effect in experiment on healthy rabbits.
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Base de dados:
MEDLINE
Assunto principal:
Timolol
/
Fosfatos de Cálcio
/
Sistemas de Liberação de Medicamentos
/
Nanopartículas
/
Pressão Intraocular
Idioma:
Ru
Ano de publicação:
2012
Tipo de documento:
Article