C3'/C4'-Stereochemical Effects of Digitoxigenin α-L-/α-D-Glycoside in Cancer Cytotoxicity.
ChemMedChem
; 8(1): 63-9, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-23139074
ABSTRACT
Sweet'n low in stereo A Wharton reaction was employed along with a diastereoselective palladium-catalyzed glycosylation and other post-glycosylation transformations to synthesize digitoxin analogues. Cytotoxic evaluation against a panel of cancer cell lines uncovered the stereochemical and substitutional limits of the C3'/C4'-hydroxy functionality in digitoxin monosaccharide.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Digitoxigenina
/
Digitoxina
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article