Antibody response to Mycobacterium tuberculosis p27-PPE36 antigen in sera of pulmonary tuberculosis patients.
Tuberculosis (Edinb)
; 93(2): 189-91, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23140854
ABSTRACT
We have expressed, characterized and studied the immune response of mice against the Mycobacterium tuberculosis PPE36 protein. This protein encoded by the gene Rv2108 is a 27-kDa cell-wall associated protein. Here, we compare the antibody isotypes distribution of p27-PPE36 in sera of pulmonary tuberculosis patients and in sera from healthy control subjects by enzyme-linked immunosorbent assay (ELISA). We detected in the sera of affected individuals a significant increase of IgA antibody response, a no significant augmentation of IgM response, a complete lack of IgG2, 3, and 4 responses and a weak IgG1 response in a few subjects.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
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Tuberculose Pulmonar
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Lipoproteínas
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Anticorpos Antibacterianos
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Mycobacterium tuberculosis
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Antígenos de Bactérias
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article