Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 receptor ligands.
Bioorg Med Chem Lett
; 22(24): 7431-5, 2012 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-23141912
4-(Piperazin-1-yl methyl)-N(1)-arylsulfonyl indole derivatives were designed and synthesized as 5-HT(6) receptor (5-HT(6)R) ligands. The lead compound 6a, from this series shows potent in vitro binding affinity, good PK profile, no CYP liabilities and activity in animal models of cognition.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
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Receptores de Serotonina
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Inibidores Enzimáticos
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Indóis
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article