Multislice cardiac arterial spin labeling using improved myocardial perfusion quantification with simultaneously measured blood pool input function.
Magn Reson Med
; 70(4): 1125-36, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23168945
ABSTRACT
PURPOSE:
Myocardial blood flow (MBF) is an important indicator of cardiac tissue health, which can be measured using arterial spin labeling. This study aimed to develop a new method of MBF quantification with blood pool magnetization measurement ("bpMBF quantification") that allows multislice cardiac arterial spin labeling. THEORY ANDMETHODS:
A multislice segmented ECG-gated Look-Locker T1 mapping sequence was validated. Quantification of multislice arterial spin labeling is not straightforward due to the large volume of blood inverted following slice-selective inversion. For bpMBF quantification, a direct measurement of the left-ventricle blood pool magnetization was used to approximate the blood input function into the Bloch equations. Simulations and in vivo measurements in the mouse heart were performed to evaluate the bpMBF method.RESULTS:
Measurements indicated that blood pool magnetization requires â¼3 s to return to equilibrium following slice-selective inversion. Simulation and in vivo results show that bpMBF quantification is robust to variations in slice-selective thickness and therefore applicable to multislice acquisition, whereas traditional methods are likely to underestimate multislice perfusion. In vivo, single and multislice perfusion values matched well when quantified using bpMBF.CONCLUSION:
The first multislice cardiac arterial spin labeling technique has been presented, which can be used for accurate perfusion measurements in studies of cardiac disease.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Interpretação de Imagem Assistida por Computador
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Aumento da Imagem
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Angiografia por Ressonância Magnética
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Imagem Cinética por Ressonância Magnética
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Circulação Coronária
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Vasos Coronários
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Imagem de Perfusão do Miocárdio
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article