Topical gel therapy for sinonasal polyposis in Samter's triad: preliminary report.
Ann Otol Rhinol Laryngol
; 121(11): 719-24, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-23193904
ABSTRACT
OBJECTIVES:
Rhinosinusitis and polyposis are difficult to treat in patients with Samter's triad; they commonly recur despite sinus surgery, antibiotics, and/or nasal steroids. The present study assesses the efficacy of a multimodal regimen that includes topical corticosteroids and antibiotics delivered through a hydroxyethyl cellulose gel and by nebulization.METHODS:
Eleven patients with Samter's triad who had polyposis and rhinosinusitis that recurred despite endoscopic sinus surgery were treated with a 6-week course of multimodal topical therapy consisting of a hydroxyethyl cellulose gel that releases corticosteroids and antibiotics, topical nebulization of corticosteroids and antibiotics, saline solution rinses, and sinus debridement. Clinical outcomes were evaluated by Lund-Kennedy endoscopic and symptom scores. Histologic assessment was evaluated by hematoxylin and eosin staining before and after treatment.RESULTS:
Both Lund-Kennedy symptom and endoscopic scores showed.a progressive and statistically significant decline throughout the course of treatment, reaching at 6 weeks 42% of the pretreatment values (p = 0.005) for the Lund-Kennedy symptom score and 34% (p = 0.002) for the endoscopic score, respectively; however, the significance of the improvement was lost with time.CONCLUSIONS:
Topical gel therapy improves clinical symptoms, endoscopic findings, and sinus membrane histologic features in patients with refractory Samter's triad, but the improvement is transient, suggesting that a longer therapeutic period might be needed.
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Base de dados:
MEDLINE
Assunto principal:
Pregnadienodiois
/
Sinusite
/
Rinite
/
Pólipos Nasais
/
Endoscopia
/
Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article