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Large decrease of anti-tetanus anatoxin and anti-pneumococcal antibodies at one year after renal transplantation.
Broeders, Emine Nilufer; Wissing, Karl M; Ghisdal, Lidia; Lemy, Anne; Hoang, Anh-Dung; Vereerstraeten, Pierre; Mascart, Françoise; Abramowicz, Daniel.
Afiliação
  • Broeders EN; Universite Libre de Bruxelles, Brussels, Belgium. ebroeder@ulb.ac.be
Clin Nephrol ; 79(4): 313-7, 2013 Apr.
Article em En | MEDLINE | ID: mdl-23211343
ABSTRACT

AIMS:

In kidney transplant recipients (KTR), antibody (Ab) synthesis is hampered by AZA and CsA. We here report in a prospective cohort study, the effects of mycophenolate mofetil (MMF) associated to a calcineurin inhibitor on plasma levels of anti-tetanus anatoxin Ab (TAnAb) and anti-pneumococcal Ab (PnPsAb).

METHODS:

Serum titers of the TAnAb and the PnPsAb against serotypes 14, 19F and 23F were measured in 94 KTR on Day 0 (T0) and 1 year (T12) after renal transplantation and in 49 healthy controls.

RESULTS:

1) At T0, TAnAb were detected in only 71% of patients vs. 98% of controls (p < 0.0001) and the titers were significantly lower in KTR (1.46 UI/ml vs. 2.74 in controls, p = 0.01); they further decreased between T0 and T12 (1.46 UI/ml to 0.31, p < 0.0001). The calculated half-life (t1/2) of TAnAb was 7.7 months, as compared to more than 10 years in a normal population. 2) In KTR, PnPsAb titers decreased significantly between T0 and T12 (p < 0.005); the t1/2 of the different PnPsAb ranged from 9.2 to 11.9 months.

CONCLUSIONS:

In KTR treated by MMF and CNI, the TAnAbs and PnPsAbs titers decrease significantly and profoundly during the first year. Immunization pre-transplantation should be encouraged to maintain adequate post-transplant Abs levels.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoide Tetânico / Transplante de Rim / Vacinas Pneumocócicas / Imunossupressores / Anticorpos Antibacterianos Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoide Tetânico / Transplante de Rim / Vacinas Pneumocócicas / Imunossupressores / Anticorpos Antibacterianos Idioma: En Ano de publicação: 2013 Tipo de documento: Article