Niacin prevents DNA strand breakage by adenosine deaminase inhibitors.
Biochem Biophys Res Commun
; 167(2): 514-9, 1990 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-2322239
ABSTRACT
The adenosine deaminase inhibitors deoxycoformycin and erythro-9-(2-hydroxy-3 nonyl) adenine (EHNA) induce single-strand DNA breaks in cultured human lymphocytes. Deoxycoformycin produced a significant number of strand breaks (4-fold increase compared to controls) and EHNA induced strand breaks in a dose-dependent manner. Strand breaks stimulate repair by poly(ADP-ribosylation) which requires NAD+ as a cofactor. Niacin is a precursor of NAD+ and when preincubated with human lymphocytes prior to exposure to adenosine deaminase inhibitors, strand breakage was reduced significantly. The administration of niacin may represent an approach to decreasing the toxicity associated with these agents.
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Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
DNA
/
Adenina
/
Linfócitos
/
Pentostatina
/
Inibidores de Adenosina Desaminase
/
Niacina
/
Nucleosídeo Desaminases
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article