Synthesis of fluorinated cyclopropyl amino acid analogues: toward the synthesis of original fluorinated peptidomimetics.
J Org Chem
; 78(2): 212-23, 2013 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-23227990
ABSTRACT
A straightforward, easy, and practical access to various amino acid analogues (methionine, leucine, lysine, and arginine) from a unique fluorinated cyclopropane scaffold is described. Moreover, the synthesis, for the first time, of one tripeptide incorporating a fluorinated cyclopropane amino acid (FCAA) analogue is reported.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Arginina
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Ciclopropanos
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Peptidomiméticos
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Aminoácidos
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Hidrocarbonetos Fluorados
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Leucina
/
Metionina
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article