The effects of amphetamine injections on feeding behavior and the brain expression of orexin, CART, tyrosine hydroxylase (TH) and thyrotropin releasing hormone (TRH) in goldfish (Carassius auratus).
Fish Physiol Biochem
; 39(4): 979-91, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23229307
ABSTRACT
In this study, the effects of peripheral (intraperitoneal) injections of D-amphetamine on feeding behavior were assessed in goldfish. Compared with the saline-injected group, amphetamine injections decreased food intake at doses ranging from 1 to 75 µg/g, but not 0.5 µg/g, but increased locomotor behavior, as indicated by the increased number of total feeding and non-feeding acts, at doses ranging from 2.5 to 25 µg/g. Amphetamine at high doses inhibited both food intake (at 25, 50 and 75 µg/g) and feeding behavior (at 75 µg/g). In the hypothalamus, the expression of orexin was down-regulated, and both CART 1 and CART 2 expressions were up-regulated in amphetamine-treated fish (50 µg/g) as compared to saline-injected fish, but amphetamine treatment had no effect on either hypothalamic TH or TRH expression. In the telencephalon, amphetamine treatment (50 µg/g) up-regulated CART 1, CART 2 and TH mRNA expressions but had no effect on either orexin or TRH. Our results suggest that, as in mammals, the orexin, CART and TH systems might be involved in amphetamine-induced feeding/locomotor responses in goldfish.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Ingestão de Alimentos
/
Comportamento Alimentar
/
Anfetamina
/
Estimulantes do Sistema Nervoso Central
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article