α-TEA as a stimulator of tumor autophagy and enhancer of antigen cross-presentation.
Autophagy
; 9(3): 429-31, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23235369
ABSTRACT
Stimulation of apoptosis has been reported as the primary mechanism of tumor cell death induced by alpha-tocopheryloxyacetic acid (α-TEA), an esterase-resistant, semi-synthetic derivative of vitamin E (R-R-R-α-tocopherol). New information now shows that α-TEA also triggers tumor cell autophagy and promotes antigen cross-presentation. Autophagosome-enriched fractions of α-TEA-treated tumor cells (α-TAGS) efficiently cross-primed antigen-specific CD8 (+) T cells and vaccination with dendritic cells (DC) pulsed with α-TAGS reduced lung metastases and increased survival of tumor-bearing mice. Taken together, these observations suggest that both autophagy and apoptosis signaling programs are activated in tumor cells by α-TEA treatment and may contribute to tumor cell death. We propose that autophagy-dependent enhancement of cross-presentation is a novel mechanism of α-TEA-mediated tumor immunity and that α-TEA can be exploited as an adjuvant to enhance the antitumor response.
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MEDLINE
Assunto principal:
Autofagia
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Regulação Neoplásica da Expressão Gênica
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Apoptose
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Apresentação de Antígeno
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Tocoferóis
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article