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Anti-tumor effects of peptide analogs targeting neuropeptide hormone receptors on mouse pheochromocytoma cells.
Ziegler, C G; Ullrich, M; Schally, A V; Bergmann, R; Pietzsch, J; Gebauer, L; Gondek, K; Qin, N; Pacak, K; Ehrhart-Bornstein, M; Eisenhofer, G; Bornstein, S R.
Afiliação
  • Ziegler CG; University Hospital Carl Gustav Carus, Department of Medicine III, Dresden, Germany. Christian.Ziegler@uniklinikum-dresden.de
Mol Cell Endocrinol ; 371(1-2): 189-94, 2013 May 22.
Article em En | MEDLINE | ID: mdl-23267837
Pheochromocytoma is a rare but potentially lethal chromaffin cell tumor with currently no effective treatment. Peptide hormone receptors are frequently overexpressed on endocrine tumor cells and can be specifically targeted by various anti-tumor peptide analogs. The present study carried out on mouse pheochromocytoma cells (MPCs) and a more aggressive mouse tumor tissue-derived (MTT) cell line revealed that these cells are characterized by pronounced expression of the somatostatin receptor 2 (sst2), growth hormone-releasing hormone (GHRH) receptor and the luteinizing hormone-releasing hormone (LHRH) receptor. We further demonstrated significant anti-tumor effects mediated by cytotoxic somatostatin analogs, AN-162 and AN-238, by LHRH antagonist, Cetrorelix, by the cytotoxic LHRH analog, AN-152, and by recently developed GHRH antagonist, MIA-602, on MPC and for AN-152 and MIA-602 on MTT cells. Studies of novel anti-tumor compounds on these mouse cell lines serve as an important basis for mouse models of metastatic pheochromocytoma, which we are currently establishing.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Feocromocitoma / Receptores de Neuropeptídeos / Neoplasias das Glândulas Suprarrenais Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Feocromocitoma / Receptores de Neuropeptídeos / Neoplasias das Glândulas Suprarrenais Idioma: En Ano de publicação: 2013 Tipo de documento: Article