Methyl 2-[2-(benzyl-oxycarbon-ylamino)-propan-2-yl]-5-hy-droxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxyl-ate.
Acta Crystallogr Sect E Struct Rep Online
; 68(Pt 11): o3175, 2012 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-23284488
ABSTRACT
The title pyrimidine derivative, C(18)H(21)N(3)O(6), was obtained by the reaction of methyl 2-[2-(benzyl-oxycarbon-yl)amino-propan-2-yl]-5-hy-droxy-6-oxo-1,6-dihydro-pyrimidine-4-carboxyl-ate with dimethyl sulfate in dimethyl sulfoxide. The mol-ecule has a V-shaped structure, the phenyl and the pyrimidine rings making a dihedral angle of 43.1â
(1)°. The methyl group substituting the pyrimidine ring deviates slightly from the ring mean-plane [C-N-C-C torsion angle = 5.49â
(15)°], and the methyl ester substituent has a conformation suitable for the formation of an intra-molecular O-Hâ¯O hydrogen bond with the hydroxyl functionality. In the crystal, molecules are linked into chains along the b axis by N-Hâ¯O hydrogen bonds.
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MEDLINE
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En
Ano de publicação:
2012
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Article