Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system.
Eur J Neurol
; 20(11): 1492-5, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23293933
ABSTRACT
BACKGROUND:
Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between gastrointestinal immune responses and CNS autoimmunity.METHODS:
Antibodies against gliadin, tissue transglutaminase (tTG), intrinsic factor (IF), parietal cells (PC) and Saccharomyces cerevisiae (ASCA) were screened in the sera of 45 patients with AQP4-seropositive neuromyelitis optica (NMO) and NMO spectrum diseases (NMO/NMO-SD), 17 patients with AQP4-seronegative NMO, 85 patients with clinically definite multiple sclerosis (MS), and 48 healthy controls (HC).RESULTS:
Thirty-seven percentages of patients with AQP4-seropositive NMO/NMO-SD and 28% of patients with MS had at least one particular antibody in contrast to 8% of HC (P < 0.01, respectively). Antibodies were most common (46%) in AQP4-seropositive myelitis (P = 0.01 versus HS, P = 0.05 versus MS). Anti-gliadin and ASCA were more frequent in the AQP4-seropositive NMO-spectrum compared to controls (P = 0.01 and P < 0.05, respectively).CONCLUSION:
Antibody responses against gastrointestinal antigens are common in MS and AQP4-seropositive NMO/NMO-SD, especially in longitudinally extensive myelitis.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes Desmielinizantes do Sistema Nervoso Central
/
Gastroenteropatias
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article