Are risk factors associated with invasive pneumococcal disease according to different serotypes?
Hum Vaccin Immunother
; 9(3): 712-9, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23295982
ABSTRACT
The aim of this study was to investigate risk factors for the most common serotypes of invasive pneumococcal disease (IPD). A total of 293 IPD cases were analyzed in children aged 3-59 mo in a community with intermediate vaccination coverage with the 7-valent pneumococcal vaccine (PCV7). IPD cases were reviewed during 2007-2009 in two pediatric hospitals in Catalonia (Spain). A multivariate analysis using unconditional logistic regression was performed to estimate the adjusted odds ratio. PCV7 coverage was 45.4%. Pneumonia with empyema (64.5%) was the most frequent clinical manifestation. The most common serotypes were serotype 1 (21.2%), 19A (16.0%), 3 (12.6%) and 7F/A (6.8%). 70.0% of serotypes found were included in the 13-valent conjugate vaccine (PCV13), 39.2% in the 10-valent conjugate vaccine and 8.1% in the PCV7. PCV7 was protective in IPD cases due to PCV7-serotypes (aOR 0.15, 95% CI0.04-0.55). Serotype 1 was positively associated with attending day care or school (aOR 3.55, 95% CI 1.21-10.38) and age 24-59 mo (aOR 7.70, 95% CI2.70-21.98). Serotype 19A was positively associated with respiratory infection in the previous month (aOR 2.26, 95% CI 1.03-4.94), non-penicillin susceptible IPD (aOR 1.89, 95% CI1.13-3.16) and negatively associated with age 24-59 mo (aOR 0.19, 95% CI0.09-0.41). Serotype 3 was positively associated with vaccination (aOR 4.87, 95% CI2.05-11.59). No factors were associated with serotype 7F/A. Vaccination with pneumococcal vaccines including more serotypes may reduce the risk of disease in our setting.
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MEDLINE
Assunto principal:
Infecções Pneumocócicas
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Streptococcus pneumoniae
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article