The immune system's involvement in obesity-driven type 2 diabetes.
Semin Immunol
; 24(6): 436-42, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-23333525
ABSTRACT
Type 2 diabetes is now a worldwide epidemic, strongly correlated with an elevated incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the cross-talk between the immune system and organismal metabolism. This review discusses the connection between inflammation in adipose tissue and systemic insulin resistance, focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this metabolic disease.
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1
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
/
Obesidade
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article