Cyclin D1 G870A polymorphism and risk of colorectal cancer: a case control study.
Mol Med Rep
; 7(3): 811-5, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23354584
ABSTRACT
The present study aimed to analyse the role of cyclin D1 A870G polymorphism in modulating the susceptibility to colorectal cancer (CRC) in the Kashmiri population. The genotype distribution of the cyclin D1 gene in 130 CRC cases in comparison with 160 healthy controls was investigated. No direct significant association between cyclin D1 genotypes and CRC was observed; however, the AG and AA genotypes were found to be associated with an increased risk of CRC compared to the GG genotype, with an almost 2-fold increase in OR. This study suggests that the cyclin D1 polymorphism is associated with an increased risk of CRC in the Kashmiri population.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Ciclina D1
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Polimorfismo de Nucleotídeo Único
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article