Assessment of protective effects of pheniramine maleate on reperfusion injury in lung after distant organ ischemia: a rat model.
Vasc Endovascular Surg
; 47(3): 219-24, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23377174
ABSTRACT
OBJECTIVE:
The aim of this study is to investigate the protective effects of methylprednisolone (MP) and pheniramine maleate (PM) on reperfusion injury of lungs developing after ischemia of the left lower extremity of rats. MATERIALS ANDMETHODS:
A total of 28 randomly selected male rats were divided into 4 groups, each consisting of 7 rats. Group 1 was the control group. Group 2 was the sham group (ischemia/reperfusion [I/R]). Rats in group 3 were subjected to I/R and given PM (Ph group) and rats in group 4 were subjected to I/R and given MP (Pn group).RESULTS:
Malondialdehyde levels were significantly lower in Ph group than in I/R group (P < .05). Superoxide dismutase and glutathione peroxidase enzyme activities were found to be significantly higher in Ph group than in the I/R group (P < .05). Histological examination demonstrated that PM had protective effects against I/R injury.CONCLUSIONS:
The PM has a protective effect against I/R injury in rat lung.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Feniramina
/
Traumatismo por Reperfusão
/
Extremidade Inferior
/
Lesão Pulmonar
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Antagonistas dos Receptores Histamínicos H1
/
Isquemia
/
Pulmão
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article