[Prolonged exposure to crystalline silica Min-U-Sil-5 influences apoptosis or extracellular matrix genes expression in human bronchial epithelial cells]. / L'esposizione prolungata alla silice cristallina Min-U-Sil-5 influenza l'espressione di geni della matrice extracellulare o coinvolti nell'apoptosi in cellule epiteliali bronchiali umane BEAS-2B.
G Ital Med Lav Ergon
; 33(3 Suppl): 250-3, 2011.
Article
em It
| MEDLINE
| ID: mdl-23393848
ABSTRACT
Crystalline silica (Min-U-Sil-5) induces oxidative stress in human bronchial epithelial cells (BEAS-2B), through the intracellular accumulation of ROS that cause oxidative damage leading to the degradation of extracellular matrix (ECM) proteins and to the loss of cell adhesion molecules inducing apoptosis and genotoxic damage. This paper briefly summarizes some of the recent findings from our laboratories with emphasis on the molecular events by which the cronic and cumulative exposure to crystalline silica can induce cellular damage that promotes changes in extracellular matrix and in apoptosis gene expression.
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Base de dados:
MEDLINE
Assunto principal:
Brônquios
/
Regulação da Expressão Gênica
/
Proteínas da Matriz Extracelular
/
Apoptose
/
Dióxido de Silício
/
Células Epiteliais
Idioma:
It
Ano de publicação:
2011
Tipo de documento:
Article