Peptide ligation-desulfurization chemistry at arginine.
Chembiochem
; 14(5): 559-63, 2013 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-23426906
ABSTRACT
The utility of a new ß-thiol arginine building block in ligation-desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one-pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Compostos de Sulfidrila
/
Glicopeptídeos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article