Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes.
Molecules
; 18(2): 1762-74, 2013 Jan 29.
Article
em En
| MEDLINE
| ID: mdl-23434862
ABSTRACT
The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Éteres Cíclicos
/
Complexos de Coordenação
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Ferro
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Antioxidantes
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article