An unusual mucocutaneous syndrome with sensorineural deafness due to connexin 26 mutations.
Pediatr Dermatol
; 30(6): e138-42, 2013.
Article
em En
| MEDLINE
| ID: mdl-23442195
ABSTRACT
Mutations of the GJB2 gene, which encodes connexin 26, are related to a range of conditions associated with sensorineural deafness and keratinization disorders. We present the case of a newborn girl with sensorineural deafness, erythematous hyperkeratotic plaques on intertriginous areas, and parakeratosis on the oral and esophageal mucosa. She had an F142L mutation in exon 1 of the GJB2 gene, which was described previously in a patient with a similar phenotype.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dermatopatias Genéticas
/
Conexinas
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Perda Auditiva Neurossensorial
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article