A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors.
Bioorg Med Chem Lett
; 23(7): 2106-10, 2013 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-23453070
A series of thiazole bearing thiazolidin-4-one was discovered via high-throughput screening as non-competitive inhibitors of ADAMTS-5. Compound 31 appeared to give the best ADAMTS-5 inhibition and good selectivity over other metalloproteases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Inibidores Enzimáticos
/
Proteínas ADAM
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article