Multi-disciplinary methods to define RNA-protein interactions and regulatory networks.
Curr Opin Genet Dev
; 23(1): 20-8, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23453689
ABSTRACT
The advent of high-throughput technologies including deep-sequencing and protein mass spectrometry is facilitating the acquisition of large and precise data sets toward the definition of post-transcriptional regulatory networks. While early studies that investigated specific RNA-protein interactions in isolation laid the foundation for our understanding of the existence of molecular machines to assemble and process RNAs, there is a more recent appreciation of the importance of individual RNA-protein interactions that contribute to post-transcriptional gene regulation. The multitude of RNA-binding proteins (RBPs) and their many RNA targets has only been captured experimentally in recent times. In this review, we will examine current multidisciplinary approaches toward elucidating RNA-protein networks and their regulation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Processamento Pós-Transcricional do RNA
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Proteínas de Ligação a RNA
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Redes Reguladoras de Genes
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article